Buy High Quality Fmoc-Lys(Boc)-OH Cas 71989-26-9 For Peptide Synthesis

Fmoc-Lys(Boc)-OH is a chemical compound used in peptide synthesis, particularly in solid-phase peptide synthesis. It is a derivative of the amino acid lysine and is modified with two protecting groups: Fmoc (Fluorenylmethyloxycarbonyl) and Boc (tert-butyloxycarbonyl). These protecting groups are used to temporarily block the amino and carboxyl groups of lysine, allowing selective deprotection and coupling of amino acids in a controlled manner during the peptide synthesis process.

Here’s how Fmoc-Lys(Boc)-OH is typically used in solid-phase peptide synthesis:

Activation: Fmoc-Lys(Boc)-OH is activated by removing the Fmoc protecting group from the amino group. This is usually achieved by treating the compound with a base like piperidine. The result is an active, free amino group ready for peptide bond formation.

Coupling: The activated Fmoc-Lys(Boc)-NH2 is then coupled with the next amino acid in the peptide sequence. This coupling involves the reaction of the free amino group with the carboxyl group of the next amino acid. This step is typically done with a coupling reagent, like HBTU (2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate).

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