Buy Neuroprotective Pentapeptide CN-105 Acetate (Ac-VSRRR-Amide) CN-105 Peptide Powder
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CN-105 is an apoE-mimetic 5 amino acid peptide (acetyl-Valine-Serine-Arginine-Arginine-Arginine-amide) derived from the apoE receptor binding region by lin- earizing the polar face of the amphipathic helix involved in receptor interaction.35 CN-105 has the advantage of increased CNS penetration35 over previous larger apoE- mimetic peptides and has demonstrated efficacy in experimental intracerebral hemorrhage.35 Based on its preclinical safety and efficacy, CN-105 was granted a suc- cessful investigational new drug application by the United States Food and Drug Administration and recently com- pleted a Phase 1 clinical trial (clinical trials identifier: NCT02670824), where safety was demonstrated in both single escalating dose and multiple dosing paradigms.47 The evidence of good CNS penetration, efficacy in acute brain injury models, and reassuring safety profile suggest CN-105 may be a viable candidate drug for further clinical development as a neuroprotective agent.
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